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Contraindicated (1)pentobarbital will lessen the extent or outcome of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Lively metabolites.pentobarbital will lower the extent or influence of diltiazem by affecting hepatic/intestinal enzyme CYP